Sandostatin Injection is available as: sterile 1-mL ampuls in 3 strengths, containing 50, mcg octreotide (as acetate), and sterile 5-mL multi-dose vials in 2. Sep 3, Octreotide Acetate (Sandostatin ®) – Intravenous (IV) Dilution. Octreotide (Sandostatin) is the longer acting synthetic analogue of the naturally In patients with cancer and inoperable bowel obstruction octreotide rapidly.
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In patients with inoperable benign or malignant tumours, glycaemic control may octreotidw improved without concomitant sustained reduction in circulating insulin levels. The amount of Sandostatin bound to blood cells is negligible.
Occurrence of gastrointestinal side-effects may be reduced by avoiding meals around the time of Sandostatin s. In animals, Octreotide is a more potent inhibitor of GH, glucagon and insulin reliease than somatostatin is, with greater selectivity for GH and glucagon suppression.
To bookmark ocfreotide medicine you must sign up and log in. Depressed vitamin Ictreotide levels and abnormal Schilling’s tests have been observed in some patients receiving octreotide therapy. Known hypersensitivity to the active substance or to any of the excipients listed in section 6. Female patients of childbearing potential should be advised to use adequate contraception if necessary during treatment with octreotide see section 4.
No specific studies were conducted in juvenile rats.
Sign Up Log In Cancel. Because of its inhibitory action on growth hormone, glucagon, and insulin.
GEP endocrine tumours During the treatment of GEP endocrine tumours, there may be rare instances of sudden escape from symptomatic control by Octreotide with rapid recurrence of severe symptoms. Skin and subcutaneous tissue disorders Urticaria. Clinical improvement and symptomatic benefit occur in patients octreitide still have symptoms related to their tumours, despite previous therapies, which may include surgery, hepatic artery embolization, and various chemotherapies, e.
Table 1 Adverse drug reactions reported in clinical studies Gastrointestinal disorders Very common: Hypothyroidism, thyroid disorder e. For Patients not currently receiving octreotide acetate Begin therapy with Sandostatin Immediate-release Injection.
A maximum dose of 1.
Octreotide 100 micrograms/1ml Solution for Injection
Depending on clinical response, effect on levels of tumour-produced hormones in cases of carcinoid tumours, on the urinary excretion of 5-hydroxyindole acetic acidand on tolerability, dosage can be gradually increased to 0.
From a microbiological point of view, the diluted solution should preferably be used immediately. Proper sterile technique should be used in the preparation of parenteral admixtures to minimize the possibility of microbial contamination. As GH-secreting pituitary tumours may sometimes expand, causing serious complications e. The following adverse drug reactions, listed in Table 1, have been accumulated from clinical studies with octreotide:.
SANDOSTATIN Dosage & Rx Info | Uses, Side Effects – MPR
The effect of Sandostatin on the state of mild diabetes mellitus which frequently occurs is not marked and, in general, does not result in a reduction of requirements for insulin or oral hypoglycaemic agents. Use in children Experience with Octreotide in children is limited. H01CB02 Octreotide is a synthetic octapeptide derivative of naturally occurring somatostatin with similar pharmacological effects, but with a considerably prolongedr duration of action.
Emergency management to stop bleeding and to protect from re-bleeding owing to gastro-oesophageal varices in patients with cirrhosis. Find out more here. Gallbladder abnormalities eg, gallstones, biliary sludgeGI upset, bradycardia, conduction abnormalities, arrhythmias, hyperglycemia, hypoglycemia, hypothyroidism, injection site pain, headache, dizziness, pancreatitis, altered dietary fat absorption.
Symptomatic control and reduction of growth hormone GH and IGF-1 plasma levels in patients with acromegaly who are inadequately controlled by surgery or radiotherapy. Step 7 After the saturation period, ensure plunger is pushed all the way down in the syringe Keep plunger pressed and shake vial moderately in a horizontal direction for a minimum of 30 seconds so the powder is completely suspended uniform milky suspension.
Fertility It is not known whether octreotide has an effect on human fertility. Prevention of complications following pancreatic surgery. The product must be used immediately and any unused drug-product must be discarded.
Somatostatin analogues have been shown to inhibit gallbladder contractility and decrease bile secretion, which may lead to gallbladder abnormalities or sludge. Patients should be monitored periodically Hyperglycemia and Hypoglycemia Blood glucose levels should be monitored Antidiabetic treatment should be adjusted accordingly Nutrition Vitamin B 12 levels: Metabolism and nutrition disorders.
The most frequent adverse reactions reported during octreotide therapy include gastrointestinal disorders, nervous system disorders, hepatobiliary disorders, and metabolism and nutritional disorders. To view the changes to a medicine you must sign up and log in. Use in patients with impaired renal function Impaired renal function did not affect the total exposure AUC to octreotide administered as s.
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Skin and subcutaneous tissue disorders. Limited published data indicate that somatostatin analogues might decrease the metabolic clearance of compounds known to be metabolised by cytochrome P enzymes, which may be due to the suppression of growth hormone.
Skin and subcutaneous tissue disorders Urticaria. Table 1 Adverse drug reactions reported in clinical studies Gastrointestinal disorders Very common: Before administration the solution has to be brought to room temperature again. Use with caution in at-risk patients. Dose adjustment of medicinal products such as beta blockers, calcium channel blockers or agents to control fluid ochreotide electrolyte balance may be necessary see section 4. This non-specific tissue reaction appeared to be particular to rats.
It is important to closely follow the mixing instructions included in the packaging. Date of revision of the text.
The management of overdosage is symptomatic. Thyroid function should be monitored in patients receiving prolonged treatment with octreotide. This should be repeated as often as necessary until the prescribed duration of treatment is reached. As a precautionary measure, it is preferable to avoid the use of Octreotide during pregnancy see section 4.