We report a case of primary cutaneous infection by the emerging fungus Aspergillus ustus in an immunosuppressed patient after a domestic accident. Aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported. We report the first outbreak of invasive infection caused by A . Med Mycol. Jun;45(4) Clustering of invasive Aspergillus ustus eye infections in a tertiary care hospital: a molecular epidemiologic study of an.
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Random amplification of polymorphic DNA may give valuable clues about the clonality of A. These cases illustrate the potential for uncommon species like A. Footnotes Suggested citation for this article: The pH of the medium is not modified by the species final pH 6.
All previously reported cases occurred sporadically in diverse medical centers Ustuw A1.
Rheumatic heart disease, prosthetic valve replacement. Molecular typing by using randomly amplified polymorphic DNA RAPD and antifungal drug susceptibility testing were performed on clinical and environmental isolates recovered from our hospital from to His interests include the epidemiology of fungal infections. Journal of Clinical Microbiology. The conidia heads are columnar when mature with hemispherical or globose and generally pigmented vesicles.
An attack rate was estimated among the potentially exposed HSCT patients using as the denominator the number of patients who were admitted for HSCT from July through October and March through Septemberthe at-risk periods when cases occurred. Azzola P Jr, Habicht JM Use of lung resection and voriconazole for successful treatment of invasive pulmonary Aspergillus ustus infection.
Ustys results of molecular analyses suggest genetic similarity of isolates recovered from patients. Possible emission of a yellowish pigment. Microscopically, the conidia are large 3. Although discriminatory power of RAPD analyses has some limitations 33the composite analysis demonstrated large separations between patient isolates aaspergillus the control ATCC strain.
The isolates recovered from the 5 HSCT were genetically similar. Retrieved from ” https: International Journal of Systematic and Evolutionary Microbiology. Also, these analyses are limited by our lack of asprgillus concerning A.
Also, several patients who were not found to have A.
Development on different materials. It is commonly found in indoor environments and soil. Like other members of the genus Aspergillusthe A.
Whether death was attributable to the fungal infection, coinfections, or underlying diseases is unclear. No changes in laboratory processing or mold identification methods occurred during the study.
Aspergillus ustus | Aspergillus & Aspergillosis Website
Molecular typing of Aspergillus ustus isolates by using random amplification of polymorphic DNA. In the absence of substantial air disturbances, A. In three uwtus the cases, the patients required enucleation following cataract surgery, while the fourth involved a fatal infection in a pediatric patient hospitalized for usgus.
Its growth on edition paper is less fast and is very weak on cotton fabric. Patient 3 was in the outpatient clinic at the time of diagnosis and is, therefore, not marked on this inpatient spot map. The latter may occur in A. Sharp, demarcated white areas over dorsal hands and arms.
However, in recent years, IA has been increasingly caused by non- fumigatus Aspergillus species. Drug exposure may select for colonization or infection with resistant isolates or facilitate acquired resistance within a colonizing strain.
Estimating that patients were admitted aspergiklus HSCT during the at-risk period, the highest overall attack rate was 1. Fukuda T, Boeckh M, Carter RA Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning. Journal List Emerg Infect Dis v. This study also emphasizes the importance of establishing microbial diagnoses to the species level; information obtained is important for infection control and, possibly, to guide antifungal therapies.