Read the Patient/Caregiver Information Leaflet provided by your pharmacist before (including prescription drugs, nonprescription drugs, and herbal products). Diastat. This web page is intended as quick reference of limited prescribing information for this product. This is not intended to represent a comprehensive. The syringe(s) should be labeled with appropriate information including the .. Avoid prescribing opiate cough medications in patients taking benzodiazepines.

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Aluminum Hydroxide; Magnesium Hydroxide: Major Concomitant use of opiate agonists with benzodiazepines may cause respiratory depression, hypotension, profound sedation, and death.

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Diastat® AcuDial™: Breakthrough Seizure Control

Caution should be disatat when using these agents concurrently. Moderate Use caution if coadministration of capecitabine with diazepam is necessary, and monitor for an increase in diazepam-related adverse reactions. Use caution with this combination. Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine: Moderate Advise patients that concurrent use of deutetrabenazine and drugs that can cause CNS depression, such as diazepam, may have additive effects and worsen drowsiness or sedation.

Tricyclic antidepressants may also lower the seizure threshold leading to pharmacodynamic interactions with anticonvulsant benzodiazepines predcribing.

Diazepam can cause physical and psychological dependence, and should be used with extreme caution in patients with known, suspected or a history of substance abuse. During withdrawal, the greatest risk of seizure appears to be during the first 24 to 72 hours. Minor CNS depressants benzodiazepines can potentiate the Informagion depression caused by procarbazine therapy, so these drugs should be used together cautiously.


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Pharmacists should contact Rx Hope at 1——— for replacement product. Benzodiazepines should be withdrawn slowly, using a gradual dosage-tapering schedule. Co-administration of ivacaftor with midazolam, another CYP3A substrate, increased midazolam exposure by 1.

Moderate Concomitant use of ropinirole with other CNS depressants can potentiate the sedation effects of ropinirole. Consider diazepam use during pregnancy only when the clinical situation warrants the risk to the fetus. Maprotiline may lower the seizure threshold, so when benzodiazepines are used for anticonvulsant effects the patient should be monitored for desired clinical outcomes. Moderate CYP3A4 inhibitors, like ranolazine, may reduce the metabolism of diazepam and increase the potential for benzodiazepine toxicity.

Diastay is extensively metabolized to one major active metabolite desmethyldiazepam and two minor active metabolites temazepam 3-hydroxydiazepam and oxazepam 3-hydroxy-N-diazepamwith half-lives of 30— hours, 9.

An enhanced CNS depressant effect may occur when carbetapentane is combined with other CNS depressants dlastat benzodiazepines. The CNS depressant effects of topiramate can be potentiated pharmacodynamically by concurrent use of CNS depressant agents such as the benzodiazepines.

None of the infants showed signs of lethargy or hypoventilation. Intravenous or Oral dosage.

Moderate Delavirdine is a potent inhibitor of the CYP3A4 and increased plasma concentrations of drugs extensively metabolized by this enzyme, such as diazepam, should be expected with concurrent use of delavirdine. Ribociclib is a strong CYP3A4 inhibitor. Patients receiving oral contraceptive therapy should be observed for evidence of increased response imformation diazepam. Because of the CNS-depressant effects of magnesium sulfate, additive central-depressant effects can occur following concurrent administration with CNS depressants such as benzodiazepines.


Benzodiazepines alleviate insomnia by decreasing the latency to sleep and increasing sleep continuity and total sleep time through their effects on GABA. Moderate The plasma concentrations of diazepam may be elevated when administered concurrently with cobicistat. Moderate Vigabatrin may cause somnolence and fatigue.

Moderate Due to the primary CNS effects of aripiprazole, caution should be used when aripiprazole is given prescribiny combination with other centrally-acting medications including benzodiazepines and other anxiolytics, sedatives, and hypnotics. Moderate Teduglutide may increase absorption of benzodiazepines or other psychotropic agents because of it’s pharmacodynamic effect of improving intestinal absorption.

Drugs that can cause CNS depression, if used concomitantly with vigabatrin, may increase both the frequency and the intensity of adverse effects such as drowsiness, sedation, and dizziness. Clinicians should ensure that the caregivers of patients with refractory seizures can adequately administer diazepam rectal gel, if this route and dosage form are to be used. Your email has been sent. This action may be additive with other agents that can cause hypotension such as benzodiazepines.

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